Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence.
Cellular senescence involves epigenetic alteration, e.g.loss of H3K27me3 in Ink4a-Arf locus.Using mouse embryonic fibroblast (MEF), we here analyzed transcription and epigenetic alteration during Ras-induced senescence on genome-wide scale by chromatin immunoprecipitation (ChIP)-sequencing and microarray.Bmp2 was the most activated secreted factor